What is LOD?

Limit of detection, LOD is the lowest concentration that can be measured (detected) with statistical significance by means of a given analytical procedure.20 It is a measured quantity value, obtained by a given measurement procedure, for which the probability of falsely claiming the absence of a component in a material is β, given a probability α of falsely claiming its presence.1 Practically, it is determined on the basis of the noise level: it is most often three times as high. [1]

  1. P. Konieczka, in Comprehensive Sampling and Sample Preparation, 2012
Updated on July 22, 2020

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